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Renal Cell Carcinoma, Study notes of Pathology

Renal Cell Carcinoma And it’s associated gene.

Typology: Study notes

2022/2023

Available from 12/29/2023

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*
RENAL
CELL
CARCINOMA
:
-
is
a
malignant
renal
tumor
of
epithelial
origin
.
common
during
6th 17th
decades
.
Etiology
:
16
%
sporadic
47
Hereditary
(multifocal
,
B14)
associated
with
syndromes
Von
Hippel
Lindau
syndrome
Mereditary
Kiomyomatosis
and
Renal
Cancer
cell
syndrome
Hereditary
Papillary
Carcinoma
Birt-Hogg
Dube
Syndrome
pf3
pf4

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* RENAL CELL^ CARCINOMA^ :-

is (^) a (^) malignant renal tumor of epithelial^ origin.

common (^) during 6th 17th^ decades. Etiology : 16 %^ sporadic (^47) Hereditary (multifocal , B14) associated with (^) syndromes ↓ ① Von^ Hippel Lindau (^) syndrome ② (^) Mereditary Kiomyomatosis and Renal (^) Cancer cell (^) syndrome ③ (^) Hereditary Papillary Carcinoma ⑪ Birt-Hogg Dube (^) Syndrome

  • HISTOLOGICAL CLASSIFICATION^ OF^ RCC^ :

u ① cal^ all^ Carcinoma^ :^ alw^ VHL^ gene mutation

most common type (70%)

location :^ PCT^ epithelium

solitary a^ unilateral^ lesion

loss of UNI gene ① UNL^ protein

stimulation of all

growth degrades

HiF-

stimulation of angiogenesis ↓

↓ (^) production

of glowth^ factors