sigmatropic reactions, Study notes of Organic Chemistry

These notes explores the fundamental principles and applications of sigmatropic rearrangements, a vital class of pericyclic reactions. Students will gain an in-depth understanding of the mechanisms, stereochemistry, and thermodynamics governing these transformations. Topics include [1,j]-sigmatropic shifts, the Cope and Claisen rearrangements, and their role in natural product synthesis and modern organic methodologies. Emphasis is placed on using the Woodward–Hoffmann rules to predict reaction outcomes and identify stereoelectronic factors affecting reactivity.