Skeletal Connective Tissue
Undergraduate – Graduate
Histology Lecture Series
Larry Johnson, Professor
Veterinary Integrative Biosciences
Texas A&M University
College Station, TX 77843
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Histology Lecture: Skeletal Connective Tissue - Cartilage and Bone, Lecture notes of Histology
This undergraduate-graduate level histology lecture series by Professor Larry Johnson at Texas A&M University covers the general organization, mechanism of growth, mineral and organic constituents, and characteristics of cartilage and bone. Topics include the functions of cartilage, types of cartilage, histogenesis of cartilage and bone, and the extracellular matrix of bone.
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2021/2022
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Skeletal Connective Tissue
Undergraduate – Graduate Histology Lecture Series Larry Johnson, Professor Veterinary Integrative Biosciences Texas A&M University College Station, TX 77843
Objectives: cartilage and bone
General organization
Mechanism of growth
Mineral and organic constituents
Characteristics of cells
Cells of CT
Fibroblasts Mesenchymal cells and RBC Adipose cells Macrophage Plasma cells Mast cells and WBC
Chondroblasts Chondrocytes
Osteoblasts Osteocytes Osteoclasts
Functions
of Cartilage
Evolutionary - embryonic model for bones
https://www.youtube.com/watch?v=p-3PuLXp9Wg
Functions of Cartilage
Slides across each other easily while bearing weight (joints, articular surfaces of bones)
Cushion - cartilage has limited compressibility (joints)
No nerves and thus, no pain during compression of cartilage.
Functions
of Cartilage
General Organization of Cartilage
Matrix Type II collagen (lack of obvious periodicity) Sulfated proteoglycans (chondroitin sulfate and keratin sulfate) - stain basophilic Capable of holding water / diffusion of nutrients Avascular - gets nutrient/waste exchange from perichondrium
General Organization of Cartilage
Matrix Type II collagen (lack of obvious periodicity) Sulfated proteoglycans (chondroitin sulfate and keratin sulfate) - stain basophilic Capable of holding water / diffusion of nutrients Avascular - gets nutrient/waste exchange from perichondrium
General Organization of Cartilage
Chondrocytes / Chondroblasts
Type II
General Organization of Cartilage
Chondrocytes / Chondroblasts
Type II
Slide 133: Trachea, monkey
- Hyaline cartilage
perichondrium
Elastic Cartilage
Same as hyaline Except it has an abundant network of fine elastic fibers, found in pinna of ear, auditory canals, Eustachian tubes, and epiglottis where flexibility and reshaping are needed
DEMO SLIDE BOX 223 (F-H-48-1) – Pinna of ear, cat
Elastic cartilage
Chondrocytes Chondroblasts
Dense irregular tissue of the perichondrium
Elastic fibers
FIBROCARTILAGE
INTERMEDIATE BETWEEN
DENSE REGULAR
CONNECTIVE TISSUE
AND HYALINE
CARTILAGE
Attaches tendon/ligament to bone
NO PERICHONDRIUM
Bone
FIBROCARTILAGE
Tendon/ ligament
Chondrocytes in fibrocartilage
Fibroblast in Tendon/ligament