BIOL 4050 Study guide for EXAM II 2014
While you are responsible for all the assigned reading material, an understanding of the following
figures and the principles associated with them will be important.
Parham text Figures:
Chp5:
5.1, 5.3, 5.6, 5.7, 5.10, 5.11, 5.13, 5.14, 5.17, 5.18, 5.20, 5.21, 5.23, 5.24, 5.29, 5.30, 5.31
You are not responsible for sections 5.33, 5.34, 5.27, 5.28,
Understand TCR gene rearrangement, alpha, beta, gamma, delta chain, and pre TCR, and their
pattern of expression during development.
Know the structure of the CD3/TCR complex.
Understand the connection between the classes of MHC molecules, antigen processing, and T
cell subset (compare and contrasts)
Know the key molecules, and their roles (chaperone, digestions, transport, etc) in the loading of
MHC molecules
Know the human MHC isotypes (ie DR, DP….)
Understand alleles and haplotype
Chp7:
7.1, 7.3, 7.7, 7.9, 7.10, 7.14, 7.15, 7.16, 7.17, 7.18, 7.21
You are not responsible for
7.5, 7.6, 7.19, 7.20
Know the cells of the thymus and their functions
Understand the steps of positive and negative selection (compare and contrast), including DN,
DP, SP
Understand the key cells involved in T cell development
