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Comparing Renal Disorders: Cystitis, Pyelonephritis, Glomerulonephritis, Nephrotic Syndrom, Study notes of Pathophysiology

An in-depth comparison of various renal disorders, including cystitis and pyelonephritis, the development of acute postreptococcal glomerulonephritis, nephrotic syndrome, and different types of renal calculi. It covers etiology, pathophysiology, manifestations, complications, and laboratory changes.

Typology: Study notes

Pre 2010

Uploaded on 12/13/2009

lady77-1
lady77-1 🇺🇸

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Renal Disorders
1. Compare cystitis and pyelonephritis
Cystitis
Eitology: UTI’s, sexual activity
Pathophysiology:
Manifestations: frequency and urgency of urination, burning and pain, lower abdominal
and back discomfort, inflammation of bladder, cysts, fever (absent in adults)
Complications:
Pyelonephritis
Etiology: kidney infection, inflammation affecting the tubules.
Pathophysiology:
Manifestations: chills, fever, headache, back pain, urinary urgency, tenderness, general
malaise.
Complicatons:
Chronic pyelonephritis: cause is due to reflux
2.Describe the developmet of acute postreptococcal glomerulonephritis, including
laboratory changes and manifestations.
Development: poststreptococcal glomerulonephritis follows a streptococcal infection by
approximately 7 to 12 days; time needed for the development of antibodies.
Laboratory changes: elevated streptococcal exo- enzyme (antistreptolysin O) titer, a
decline in C3 complement and cryoglobulins in the serum
Manifestations: first sign of this disorder is the cola- colored urine. oliguria, proteinuria,
hematuria
3. Nephrotic syndrome
Etiology: diabetes mellitus, amyloidosis, SLE, and it varies with age.
Pathophysiology:
Manifestations: Renal vein thrombosis, Deep vein thrombosis, Pulmonary emboli,
atherosclerosis
Complications:
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Renal Disorders

  1. Compare cystitis and pyelonephritis Cystitis Eitology : UTI’s, sexual activity Pathophysiology: Manifestations : frequency and urgency of urination, burning and pain, lower abdominal and back discomfort, inflammation of bladder, cysts, fever (absent in adults) Complications: Pyelonephritis Etiology: kidney infection, inflammation affecting the tubules. Pathophysiology: Manifestations: chills, fever, headache, back pain, urinary urgency, tenderness, general malaise. Complicatons: Chronic pyelonephritis : cause is due to reflux 2.Describe the developmet of acute postreptococcal glomerulonephritis, including laboratory changes and manifestations. Development: poststreptococcal glomerulonephritis follows a streptococcal infection by approximately 7 to 12 days; time needed for the development of antibodies. Laboratory changes: elevated streptococcal exo- enzyme (antistreptolysin O) titer, a decline in C3 complement and cryoglobulins in the serum Manifestations: first sign of this disorder is the cola- colored urine. oliguria, proteinuria, hematuria
  2. Nephrotic syndrome Etiology: diabetes mellitus, amyloidosis, SLE, and it varies with age. Pathophysiology: Manifestations: Renal vein thrombosis, Deep vein thrombosis, Pulmonary emboli, atherosclerosis Complications:
  1. Types of renal caculi and how they may result in hydronephrosis Hydronephrosis: urine filled dilation of the renal pelvis and calices associated with progressive atrophy of the kidney due to obstruction of the outflow of urine.
  2. Calcium (oxalate & phosphate) Increased concentration of calcium in the blood and urine. Cause: immobility, bone disease, hyperparathyroidism, renal tubular acidosis.
  3. Magnesium ammonium phosphate (struvite) Forms only in alkaline urine and in the presence of bacteria that posses an enzyme called urease. Often called staghorn stones b/c of their shape.
  4. Uric acid (urate) Develops in conditions of gout and high concentrations of uric acid in the urine.
  5. Cystine These stones are rare. They are seen in cystinuria. They resemble struvite stones except that: infection is unlikely to be present.
  6. Compare and contrast acute renal failure and Chronic renal failure. Acute Renal Failure ~Seen more often in older people. ~Most common indicator of ARF is azotemia. Causes of renal failure: Prerenal failure, postrenal failure, intrinsic renal failure Chronic Renal Failure ~Occurs in four stages: diminished renal reserve, renal insufficiency, renal failure, and end stage renal disease. ~manifestations: accumulation of nitrogenous wastes, mineral and skeletal disorders, anemia and coagulation disorders, hypertension and alterations in cardiovascular function…