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Drug Class/Generic/Brand Risk Factors Antidiabetic agents Insulin insulin lispro (Humalog) insulin protamine lispro/lispro (Humalog 75/25, Humalog 50/50) insulin protamine aspart/aspart (Novolog 70/30) insulin aspart (Novolog) insulin glulisine (Apidra) insulin regular (Humulin R, Novolin R) insulin NPH (Humulin N, Novolin N) insulin NPH/regular (Humulin 70/30, Novolin 70/30) insulin glargine (Lantus) insulin detemir (Levemir) insulin Sulfonylureas glipizide (Glucotrol) glyburide (DiaBeta, Micronase) glyburide, micronized (Glynase) glimepiride (Amaryl) Meglitinides nateglinide (Starlix) repaglinide (Prandin) Hypoglycemia Cardiovascular agents Beta-blockers atenolol (Tenormin) atenolol/chlorthalidone (Tenoretic) bisoprolol (Zebeta) bisoprolol/HCTZ (Ziac) metoprolol (Lopressor, Toprol XL) metoprolol/HCTZ (Lopressor HCT) nadolol (Corgard) nadolol/bendroflumethazide (Corzide) propranolol (Inderal) acebutolol (Sectral) pindolol (Visken) carvedilol (Coreg) labetalol (Normodyne, Trandate) nebivolol (Bystolic) Alpha-blockers doxazosin (Cardura) terazosin (Hytrin) prazosin (Minipress) Orthostatic hypotension, dizziness, syncope, bradycardia, impaired cerebral perfusion
Drug Class/Generic/Brand Risk Factors Cardiovascular agents (con’t) Calcium channel blockers amlodipine (Norvasc) felodipine (Plendil) isradipine (DynaCirc) nicardipine (Cardene) nifedipine (Procardia, Adalat, Nifedical) nidoldipine (Sular) diltiazem (Cardizem, Cartia, Dilacor, Diltia, Tiazac, Taztia) verapamil (Calan, Isoptin, Verelan, Covera) Antiarrhythmics Quinidine (generic only) procainamide (Pronestyl, Procan) disopyramide (Norpace) mexiletine (Mexitil) flecainide (Tambocor) propafenone (Rhythmol) amiodarone (Cordarone) dofetilide (Tikosyn) dronedarone (Multaq) sotalol (Betapace) ibutilide (Corvert) Diuretics chlorthalidone (Hygroton) hydrochlorothiazide (HydroDiuril, Microzide) indapamide (Lozol) metolazone (Zaroxolyn) bumetanide (Bumex) furosemide (Lasix) torsemide (Demadex) spironolactone (Aldactone) spironolactone/HCTZ (Aldactazide) amiloride (Midamor) Orthostatic hypotension, dizziness, syncope, bradycardia, impaired cerebral perfusion
Drug Class/Generic/Brand Risk Factors Psychotropic Agents (con’t) Antipsychotics chlorpromazine (Thorazine) fluphenazine (Prolixin) haloperidol (Haldol) loxapine (Loxitane) molindone (Moban) perphenazine (Trilafon) thioridazine (Mellaril) thiothixene (Navane) trifluoperazine (Stelazine) aripiprazole (Abilify) asenapine (Saphris) clozapine (Clozaril) iloperidone (Fanapt) olanzapine (Zyprexa) paliperidone (Invega) quetiapine (Seroquel) risperidone (Risperdal) ziprasidone (Geodon) Sedating Antidepressants nefazodone (Serzone) trazodone (Desyrel) mirtazapine (Remeron) amitriptyline (Elavil) clomipramine (Anafranil) doxepin (Sinequan) imipramine (Norpramin) nortriptyline (Pamelor) phenelzine (Nardil) selegiline patch (Emsam) tranylcypromine (Parnate) Psychomotor impairment, sedation, orthostatic hypotension, confusion, dizziness, confusion
Drug Class/Generic/Brand Risk Factors Analgesics Opioids morphine (Roxanol, MS Contin, Avinza, Kadian) hydromorphone (Dilaudid) oxymorphone (Opana) levorphanol (generic only) codeine (generic only) codeine/APAP (Tylenol #3) hydrocodone/APAP (Lortab, Lorcet, Vicodin) oxycodone (Roxicodone, Oxy IR, Oxycodone) oxycodone/APAP (Percocet) meperidine (Demerol) fentanyl (Duragesic) methadone (Dolophine) pentazocine (Talwin) butorphanol (Stadol) nalbuphine (Nubain) buprenorphine (Buprenex) Central analgesics tramadol (Ultram) tramadol/APAP (Ultracet) tapentadol (Nucynta) NSAIDs celecoxib (Celebrex) diclofenac (Voltaren, Cataflam, Flector) diflunisal (Dolobid) etodolac (Lodine) fenoprofen (Nalfon) ibuprofen (Motrin, Advil) ketoprofen (Orudis, Oruvail) meclofenamate (Meclomen) mefenamic acid (Ponstel) meloxicam (Mobic) nabumetone (Relafen) naproxen (Naprosyn, Anaprox, Aleve) oxaprozin (Daypro) piroxicam (Feldene sulindac (Clinoril) tolmetin (Tolectin) Sedation, confusion metoclopramide (Reglan) Psychomotor impairment, sedation
Drug Class/Generic/Brand Risk Factors Anticholinergics (con’t) Antimuscarinics oxybutynin (Ditropan) tolterodine (Detrol) trospium (Sanctura) solifenacin (Vesicare) darifenacin (Enablex) fesoterodine (Toviaz) Antispasmodics atropine (various combinations) belladonna alkaloids (various combinations) dicyclomine (Bentyl) hyoscyamine (Levsin, Lesinex) propantheline (generic only) scopalamine (Tranderm Scop) clidinium/chlordiazepozide (Librax) atropine/hyoscyamine/phenobarbital/scopolamine (Donnatal) hyoscyamine/methenamine/phenyl salicylate (Urised, Prosed) Skeletal muscle relaxants carisoprodol (Soma) chlorzoxazone (Parafon Forte DSC) cyclobenzaprine (Flexeril) metaxalone (Skelaxin) methocarbamol (Robaxin) orphenadrine (Norflex) Sedation, confusion Compiled by: Linda Sobeski Farho, PharmD, BCPS
