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Transcription: Enhancers and silencers, Study notes of Genetics

Promotors Transcription factors Gene expression

Typology: Study notes

2021/2022

Uploaded on 09/22/2023

Riya3003
Riya3003 🇮🇳

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Enhancers and silencers
Promotors
Transcription factors
control the binding of RNA polymerase to DNA
100 - 1000 base pairs long
In eukaryotes ,helper proteins ( transcription factors) first bind to the promotor
eukaryotic promotors have TATA box . It is recognized by one of the general
transcription factors allowing other TF and RNA polymerase to bind .contains a lot
of As and Ts (easy for DNA to pull the strand)
TF is a protein controls the rate of transcription of genetic information from DNA
to MRNA
The function of TF is to regulate (On and off) the genes to make sure they are
active at the right time and right cell and in the right amount in the life of cell and
organisms
DNA binding domain(DBD) attach to specific sequences that are upstream to
regulated gene . This specific region is known as promotors
Transactivation domain (TAD) is where co regulatory proteins attach to TF
Signal sensing domain (SSD) allows signaling molecules to bind to TF
pf3
pf4

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Enhancers and silencers

Promotors

Transcription factors

control the binding of RNA polymerase to DNA 100 - 1000 base pairs long In eukaryotes ,helper proteins ( transcription factors) first bind to the promotor eukaryotic promotors have TATA box. It is recognized by one of the general transcription factors allowing other TF and RNA polymerase to bind .contains a lot of As and Ts (easy for DNA to pull the strand)

TF is a protein controls the rate of transcription of genetic information from DNA to MRNA The function of TF is to regulate (On and off) the genes to make sure they are active at the right time and right cell and in the right amount in the life of cell and organisms DNA binding domain(DBD) attach to specific sequences that are upstream to regulated gene. This specific region is known as promotors Transactivation domain (TAD) is where co regulatory proteins attach to TF Signal sensing domain (SSD) allows signaling molecules to bind to TF

Gene expression Activator proteins bind to enhancer/silencer DNA bending protein bring bound activators closer to promotors Activators bind to TF and mediator proteins forming a Transcription complex factors. this promotes the binding of RNA polymerase to promotor