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Trigeminal Neuralgia: Symptoms, Pathophysiology, Diagnosis and Treatment, Study notes of General Surgery

Trigeminal Neuralgia (TN) is a neuropathic condition characterized by severe episodes of electric or lancinating pain along the cranial nerve V distribution. the pathophysiology, symptoms, diagnosis, and treatment of TN. It also discusses the triggers that may set off the pain of TN. the neurological examination and MRI scan that doctors conduct to diagnose TN. The treatment options for TN include drugs and surgery. the drugs used to treat TN and their side effects. It also discusses muscle-relaxing agents and their side effects. Surgery is the last resort for treating TN.

Typology: Study notes

2022/2023

Available from 01/23/2024

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TRIGEMINAL NEURALGIA
Tic douloureux is another name for trigeminal neuralgia (TN).
It is a very frequent neuropathic condition characterized by abrupt, severe episodes of
electric or lancinating pain along the cranial nerve V (CN V) distribution.
TN is still one of the most common causes of facial pain in the world.
Women experience it marginally more frequently than men do.
Although few cases have been observed in childhood, TN often manifests itself after the fifth
decade of life.
PATHOPHYSIOLOGY :-
In recent years there has been significant progress in our understanding of the pathogenesis
of TN. This disease is divided into two major categories due to the reason for the cause, but
in both categories the type of disease is the reduction of the trigeminal nerve. Degeneration
refers to the destruction of the protective protective coating (myelin) on the outside of
neurons. Without myelin, nerve conduction is impaired, hearing, movement, etc. In classic
TN, blood vessels impinge on the trigeminal nerve, producing regional demyelination. Thus,
arteriolar stiffening that occurs with aging is more evident in increased TN after age 50.
This compression-induced reduction is also seen in secondary forms of TN caused by
tumors. In addition, there is evidence of multiple sclerosis, another common secondary
etiology, neuronal demyelination, providing further evidence that this mechanism plays an
important role in the pathogenesis of TN. The association between demyelination of the
trigeminal nerve and persistent pain attacks indicates that this disease affects the various
functions of the fifth cranial nerve. As mentioned above, the trigeminal nerve carries tactile,
pain, and motor fibers involving parts of the face. Affected nerve fibers have large diameters
and a large amount of myelin around them, while pain fibers are smaller in diameter and
have less myelin around their boundaries. When a contraction occurs, the trigeminal nerve
and pain nerves are connected to each other, electrically connected and weakened. tactile,
means Crosstalk between nerve fibers. . The presence of ephaptic transmission
demonstrates that even small movements of the patient's face can trigger episodes of pain.
SYMPTOMS :-
•Occasional twinges of mild pain
Episodes of severe, shooting or jabbing pain that may feel like an electric shock
Spontaneous attacks of pain or attacks triggered by things such as touching the face,
chewing, speaking and brushing teeth
Bouts of pain lasting from a few seconds to several seconds
Episodes of several attacks lasting days, weeks, months or longer some people have
periods when they experience no pain
Pain in areas supplied by the trigeminal nerve, including the cheek, jaw, teeth, gums, lips,
or less often the eye and forehead
Pain affecting one side of your face at a time
Pain focused in one spot or spread in a wider pattern
Attacks becoming more frequent and intense over time.
Triggers :-
A variety of triggers may set off the pain of trigeminal neuralgia, including:
•Shaving
•Stroking your face
•Eating
•Drinking
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TRIGEMINAL NEURALGIA

Tic douloureux is another name for trigeminal neuralgia (TN). It is a very frequent neuropathic condition characterized by abrupt, severe episodes of electric or lancinating pain along the cranial nerve V (CN V) distribution. TN is still one of the most common causes of facial pain in the world. Women experience it marginally more frequently than men do. Although few cases have been observed in childhood, TN often manifests itself after the fifth decade of life. PATHOPHYSIOLOGY :- In recent years there has been significant progress in our understanding of the pathogenesis of TN. This disease is divided into two major categories due to the reason for the cause, but in both categories the type of disease is the reduction of the trigeminal nerve. Degeneration refers to the destruction of the protective protective coating (myelin) on the outside of neurons. Without myelin, nerve conduction is impaired, hearing, movement, etc. In classic TN, blood vessels impinge on the trigeminal nerve, producing regional demyelination. Thus, arteriolar stiffening that occurs with aging is more evident in increased TN after age 50. This compression-induced reduction is also seen in secondary forms of TN caused by tumors. In addition, there is evidence of multiple sclerosis, another common secondary etiology, neuronal demyelination, providing further evidence that this mechanism plays an important role in the pathogenesis of TN. The association between demyelination of the trigeminal nerve and persistent pain attacks indicates that this disease affects the various functions of the fifth cranial nerve. As mentioned above, the trigeminal nerve carries tactile, pain, and motor fibers involving parts of the face. Affected nerve fibers have large diameters and a large amount of myelin around them, while pain fibers are smaller in diameter and have less myelin around their boundaries. When a contraction occurs, the trigeminal nerve and pain nerves are connected to each other, electrically connected and weakened. tactile, means Crosstalk between nerve fibers.. The presence of ephaptic transmission demonstrates that even small movements of the patient's face can trigger episodes of pain. SYMPTOMS :- •Occasional twinges of mild pain

  • Episodes of severe, shooting or jabbing pain that may feel like an electric shock
  • Spontaneous attacks of pain or attacks triggered by things such as touching the face, chewing, speaking and brushing teeth
  • Bouts of pain lasting from a few seconds to several seconds
  • Episodes of several attacks lasting days, weeks, months or longer — some people have periods when they experience no pain
  • Pain in areas supplied by the trigeminal nerve, including the cheek, jaw, teeth, gums, lips, or less often the eye and forehead
  • Pain affecting one side of your face at a time
  • Pain focused in one spot or spread in a wider pattern
  • Attacks becoming more frequent and intense over time. Triggers :- A variety of triggers may set off the pain of trigeminal neuralgia, including: •Shaving •Stroking your face •Eating •Drinking

•Brushing your teeth •Talking •Putting on makeup •Encountering a breeze •Smiling •Washing your face TESTS AND DIAGNOSIS :- Your doctor will diagnose trigeminal neuralgia mainly based on your description of the pain, including: Type. Pain related to trigeminal neuralgia is sudden, shock-like and brief. Location. The parts of your face that are affected by pain will tell your doctor if the trigeminal nerve is involved. Triggers. Trigeminal neuralgia-related pain usually is brought on by light stimulation of your cheeks, such as from eating, talking or even encountering a cool breeze. Your doctor may conduct many tests to diagnose trigeminal neuralgia and determine underlying causes for your condition, including: A neurological examination:- Touching and examining parts of your face can help your doctor determine exactly where the pain is occurring and — if you appear to have trigeminal neuralgia — which branches of the trigeminal nerve may be affected. Your doctor also may conduct reflex tests to determine if your symptoms are caused by a compressed nerve, or if another condition is causing your symptoms. Magnetic resonance imaging (MRI):- Your doctor may order an MRI scan of your head to determine if multiple sclerosis or a tumor is causing trigeminal neuralgia. Sometimes your doctor may inject a dye into a blood vessel to view the arteries and veins and highlight blood flow (magnetic resonance angiogram). Your facial pain may be caused by many different conditions, so an accurate diagnosis is important. Your doctor may order additional tests to rule out other conditions. TREATMENT :-

  1. Drugs
  2. Surgery Drugs Anticonvulsants:- Doctors usually prescribe carbamazepine (Tegretol, Carbatrol, others) for trigeminal neuralgia, and it's been shown to be effective in treating the condition. Other anticonvulsant drugs that may be used to treat trigeminal neuralgia include oxcarbazepine (Trileptal). Other drugs, including clonazepam (Klonopin) and gabapentin (Neurontin, Gralise, others), also may be used. If the anticonvulsant you're using begins to lose effectiveness, your doctor may increase the dose or switch to another type. Side effects of anticonvulsants may include dizziness, confusion, drowsiness, double vision and nausea. Also, carbamazepine can trigger a serious drug reaction in some people, mainly those of Asian descent, so genetic testing may be recommended before you start carbamazepine. Antispasmodic agents:- Muscle-relaxing agents such as baclofen (Gablofen, Lioresal) may be used alone or in combination with carbamazepine. Side effects may include confusion, nausea and drowsiness. Surgery

your face and guides it to a part of the trigeminal nerve that goes through an opening at the base of your skull. Once the needle is positioned, your surgeon will wake you from sedation. Your surgeon inserts an electrode through the needle and sends a mild electrical current through the tip of the electrode. You'll be asked to indicate when and where you feel tingling. When your neurosurgeon locates the part of the nerve involved in your pain, you're returned to sedation. Then the electrode is heated until it damages the nerve fibers, creating an area of injury (lesion). If your pain isn't eliminated, your doctor may create additional lesions. Radiofrequency thermal lesioning usually results in some temporary facial numbness after the procedure.