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Unit 3 UNE Biochem Test 100% Accurate Review Solution Update 2023-2024 A+, Exams of Biochemistry

1. An individual goes to bed around 8 pm and doesn't wake up until 9 am the next morning . During this time, which of the following is the primary oxidizable substrate in the skeletal muscle? - ANS-Free fatty acids 2. The process of ketogenesis refers to the conversion of acetyl CoA to which of the following compounds? - ANS-D-3-hydroxybutyrate or beta hydroxybutyrate 3. Under fasting conditions, elevated glucagon will activate which of the following enzymes? - ANSHormone sensitive lipase

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2023/2024

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Unit 3 UNE Biochem Test 100% Accurate Review Solution Update 2023-2024 A+
1. An individual goes to bed around 8 pm and doesn't wake up until 9 am the next morning .
During this time, which of the following is the primary oxidizable substrate in the skeletal
muscle? - ANS-Free fatty acids
2. The process of ketogenesis refers to the conversion of acetyl CoA to which of the following
compounds? - ANS-D-3-hydroxybutyrate or beta hydroxybutyrate
3. Under fasting conditions, elevated glucagon will activate which of the following enzymes? - ANS-
Hormone sensitive lipase
4. In the fasted state, fatty acyl CoAs are transported across the mitochondrial membrane. The
transport of fatty acids via CPT1 can be directly inhibited by which of the following compounds?
- ANS-Malonyl CoA
5. In liver, which of the following key inhibitory events ensures that newly synthesized palmitoyl
CoA is not immediately oxidized? - ANS-Inhibition of CPT1 by malonyl CoA
6. During the fasted state, lipolysis is facilitated by the action of hormone sensitive lipase. This
enzyme requires which of the following modifications for activation? - ANS-phosphorylation
7. Which of the following is NOT a product of beta oxidation? - ANS-NADPH
8. A 12 year old male is brought to his primary care physician. His parents are concerned with his
recent decline in school work due to persistent blurred vision. On physical exam, planar
xanthomas are noted and laboratory testing reveals extremely low plasma HDL. The
presentation would be consistent with the LOSS of which of the following apoproteins? - ANS-
ApoA
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Unit 3 UNE Biochem Test 100% Accurate Review Solution Update 2023-2024 A+

  1. An individual goes to bed around 8 pm and doesn't wake up until 9 am the next morning. During this time, which of the following is the primary oxidizable substrate in the skeletal muscle? - ANS-Free fatty acids
  2. The process of ketogenesis refers to the conversion of acetyl CoA to which of the following compounds? - ANS-D-3-hydroxybutyrate or beta hydroxybutyrate
  3. Under fasting conditions, elevated glucagon will activate which of the following enzymes? - ANS- Hormone sensitive lipase
  4. In the fasted state, fatty acyl CoAs are transported across the mitochondrial membrane. The transport of fatty acids via CPT1 can be directly inhibited by which of the following compounds?
    • ANS-Malonyl CoA
  5. In liver, which of the following key inhibitory events ensures that newly synthesized palmitoyl CoA is not immediately oxidized? - ANS-Inhibition of CPT1 by malonyl CoA
  6. During the fasted state, lipolysis is facilitated by the action of hormone sensitive lipase. This enzyme requires which of the following modifications for activation? - ANS-phosphorylation
  7. Which of the following is NOT a product of beta oxidation? - ANS-NADPH
  8. A 12 year old male is brought to his primary care physician. His parents are concerned with his recent decline in school work due to persistent blurred vision. On physical exam, planar xanthomas are noted and laboratory testing reveals extremely low plasma HDL. The presentation would be consistent with the LOSS of which of the following apoproteins? - ANS- ApoA
  1. A 16 year old woman presents to her pcp for a f/u visit. At her initial visit, 3 mo ago, her serum cholesterol was 255 mg/dL (above normal). Today her serum triglycerides are reported to be 260 mg/dL (above normal). She finds this very disappointing as she started a strict dietary regimen reducing all fats and cholesterol, replacing them with a high carb diet. You tell her that high carb diets can increase serum triglyceride levels in some individuals. This can be attributed to an increase in the synthesis of which of the following lipoproteins? - ANS-VLDL
  2. Nascent chylomicrons are synthesized in which of the following organs? - ANS-Intestine
  3. Which of the following is the major source of extracellular cholesterol for human tissues? - ANS- LDLs
  4. Lethicin:cholesterol acyl transferase (LCAT) is a plasma enzyme associated with HDL particles. Which of the following best describes its role in the cholesterol transport? - ANS-Esterifies cholesterol to trap it in HDL particles
  5. Nascent chylomicrons interact with HDL particles within circulation. Which of the following Apo proteins are obtained from HDL during this interaction? - ANS-Apo CII and Apo E
  6. The interaction of chylomicrons with lipoprotein lipase is stimulated by which of the following apo proteins? - ANS-Apo C II
  7. Which of the following is NOT required for the transport of newly synthesized fatty acids to the adipose? - ANS-Carnitine to shuttle the fatty acids out of the mitochondria
  8. Which of the following enzymes is correctly paired with its allosteric inhibitor? - ANS-acetyl CoA carboxylase: palmitoyl CoA
  9. Under fasting conditions, acetyl CoA carboxylase will be inhibited by an increase in which of the following compounds? - ANS-fatty acyl CoA
  1. The cellular uptake of LDL increases intracellular cholesterol levels. This has which of the following impacts on de novo cholesterol synthesis? - ANS-increases degradation of HMG-CoA reductase
  2. The LDL receptor is also highly regulated in the cell. Which of the following proteins targets the LDL receptor for degradation? - ANS-PSK
  3. Under cellular conditions when cholesterol is low, which of the following is a true statement regarding the sterol response element binding protein? - ANS-It will be associate with the sterol response element (SRE) in the DNA
  4. When an LDL particle is taken up by the cell, what impact will this have on the regulation of de novo cholesterol synthesis? - ANS-SREBP will be inhibited by Insig in the endoplasmic reticulum