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Anatomy and Function of the Urinary System: Filtration, Reabsorption, and Secretion - Prof, Study notes of Physiology

An in-depth exploration of the urinary system, focusing on its functions, anatomy, and the processes of filtration, reabsorption, and secretion. The roles of the kidneys, nephrons, and various structures such as the glomerulus, bowman's capsule, and juxtaglomerular apparatus. It also discusses the mechanisms of urine formation, including glomerular filtration, tubular reabsorption, and tubular secretion. Additionally, the document explains the importance of maintaining proper urine concentration and volume through the countercurrent mechanism.

Typology: Study notes

2011/2012

Uploaded on 02/07/2012

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Urinary System
Functions:
1. Filter blood for toxins, metabolic wastes, and excess ions
2. Regulate blood volume
3. Regulate salt and water levels in blood
4. Produce renin that acts in blood pressure regulation
5. Produce erythropoietin to stimulate red blood cell production
Kidney anatomy
- retroperitoneal
- hilus = vertical cleft permits entry and exit of blood and lymphatic vessels, nerves, and ureters
Fibrous coverings:
1. Renal capsule - adheres to surface of kidney
2. Adipose capsule - helps to hold kidney in place
3. Renal fascia - outer covering of dense fibrous connective tissue
Internal anatomy
1. Renal cortex
- renal columns - inward extensions of cortical tissue
2. Renal medulla
- renal pyramids - cone shaped tissue masses formed from collecting tubules
- lobe = each pyramid and a portion of associated cortex
3. Renal pelvis
- major calyx
- minor calyx
Nephron
- functional unit of kidney
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Urinary System Functions:

  1. Filter blood for toxins, metabolic wastes, and excess ions
  2. Regulate blood volume
  3. Regulate salt and water levels in blood
  4. Produce renin that acts in blood pressure regulation
  5. Produce erythropoietin to stimulate red blood cell production Kidney anatomy
  • retroperitoneal
  • hilus = vertical cleft permits entry and exit of blood and lymphatic vessels, nerves, and ureters Fibrous coverings:
  1. Renal capsule - adheres to surface of kidney
  2. Adipose capsule - helps to hold kidney in place
  3. Renal fascia - outer covering of dense fibrous connective tissue Internal anatomy
  4. Renal cortex
  • renal columns - inward extensions of cortical tissue
  1. Renal medulla
  • renal pyramids - cone shaped tissue masses formed from collecting tubules
  • lobe = each pyramid and a portion of associated cortex
  1. Renal pelvis
  • major calyx
  • minor calyx Nephron
  • functional unit of kidney

Parts:

  1. Glomerulus
  • capillaries associated with a renal tubule
  • tunica intima is highly fenestrated
  1. Bowman’s (glomerular) capsule
  • beginning of renal tubule
  • surrounds glomerulus
  • bilayered
  1. Parietal layer - simple squamous epithelium
  2. Visceral layer - consists of cells called podocytes
  3. Renal capsule
  • combination of glomerulus and Bowman’s capsule
  1. Proximal convoluted tubule
  2. Loop of Henle
  3. Distal Convoluted tubule
  4. Collecting duct Location of Nephrons
  5. Cortical
  • corpuscles are located well into the cortex
  1. Juxtamedullary
  • corpuscles located close to medulla, loop of Henle extends deep into medulla Capillary Beds of Nephrons
  1. Glomerulus
  • afferent arteriole
  • efferent arteriole

I. Glomerular filtration

  • passive process
  • fluids and solutes are forced through membrane by hydrostatic pressure Net filtration pressure
  • approximately 10 mm Hg Glomerular filtration rate (GFR)
  • total amount of filtrate formed per minute in kidneys Factors:
  1. Total surface area available
  2. Filtration membrane permeability
  3. Net filtration pressure
  • normal GFR in both kidneys of an adult = 180L per day
  • GFR is directly proportional to net filtration pressure
  • an increase in arterial blood pressure = increased GFR
  • dehydration = decrease in GFR because of increase in glomerular osmotic pressure Regulation of Glomerular Filtration
  • important to control because it is related to reabsorption in tubules
  • too much filtrate makes it difficult to reabsorb important substances
  • too little facilitates reabsorption of too much, including wastes
  1. Renal autoregulation
  • intrinsic mechanism Two types of controls
    1. Myogenic mechanism
      • smooth muscle cells constrict when pressure is too high
      • helps to restrict blood flow and lower downstream pressure
  • cells will relax when systemic pressure is too low, thus allowing maximum flow
  1. Tubuloglomerular feedback mechanism
  • directed by macula densa
  • slow moving, low osmotic pressure stimulates cells to secrete chemical that dilates afferent arterioles
  • fast moving, high osmotic pressure produces vasoconstriction
  1. Sympathetic nervous system controls
  • during times of stress
  • sympathetic fibers stimulate release of epinephrine
  • causes strong constriction of afferent arterioles
  1. Renin-Angiotensin mechanism
  • begins as release of renin by (juxtaglomerular) JG cells
  • activates smooth muscle of arterioles throughout body
  • also stimulates adrenal cortex to produce aldosterone
  • Aldosterone stimulates reclamation of Na+
  • this increases osmotic pressure
  • more angiotensin receptors on efferent arteriole, causes more intense constriction than afferent arteriole Renin release is dependent on:
  1. Reduced stretch of JG cells
  2. Stimulation of JG cells activated by macula densa
  3. Direct stimulation of JG cells by sympathetic neurons
  • main purpose of renin-angiotensin mechanism is to stabilize systemic blood pressure and extracellular blood volume II. Tubular reabsorption
  • begins as soon as filtrate enters proximal convoluted tubule
  • transport is transepithelial
  • K+^ and Na+^ sometimes follow paracellular pathway

Absorption in regions of the renal tubule

  1. proximal convoluted tubule
  • all glucose, lactate, and amino acids
  • 65-70% of Na+^ and water
  • bulk of actively transported substances
  1. loop of Henle
  • water reabsorption is not coupled with solute reabsorption
  • plays vital role in producing dilute or concentrated urine
  1. Distal convoluted tubule and collecting duct
  • fine-tuning of Na+^ and water reabsorption into blood
  • controlled by aldosterone and atrial natriurectic hormone III. Tubular secretion
  • substances such as H+, K+, creatinine, and ammonium ions move from blood to tubules
  • therefore, urine consists of filtered and secreted substances Tubular secretion important for:
  1. Disposing of substances not in filtrate such as some drugs
  2. Eliminating undesirable substances that have been reabsorbed
  3. Ridding body of excess K+^ ions
  4. Controlling blood pH Regulation of urine concentration and volume Osmolality - number of solute particles dissolved in 1L of water
  • crucial function of kidney is to keep body fluids at 300 mosm, similar to plasma Countercurrent mechanism
  • flow of filtrate through loop of Henle
  • flow of blood through vasa recta

Loop of Henle (countercurrent multiplier)

  1. Descending limb is impermeable to solutes and permeable to water
  • osmolality of filtrate increases to 1200 at bottom of loop
  1. Ascending limb is impermeable to water and actively transports NaCl to interstitial fluid
  • Na+ and Cl- are extruded by ascending limb
  • filtrate becomes increasingly dilute
  • as water moves from descending limb, filtrate becomes more "salty"
  • this salt is removed from the ascending limb and put into interstitial fluid
  • the added salt increases the osmolality of the interstitial fluid which in turn draws water from the descending limb
  • this process is a positive feedback mechanism that produces high osmolality of filtrate and interstitial fluid
  • the opposite flow of filtrate in each limb = countercurrent
  • the process of increasing osmolality = multiplier
  1. Collecting ducts in deep medullary regions are permeable to urea
  • this adds to high osmolality of interstitial fluid
  1. Vasa recta acts as countercurrent exchanger
  • blood flow is very slow
  • freely permeable to both water and salt
  • blood entering and leaving medulla has same concentration
  • helps to maintain gradient and perform cell exchange at same time O.k. but so what? The mechanism of the Loop has two benefits:
  1. Establishes a vertical osmotic gradient in the medulla
  • gradient is used to concentrate urine
  • therefore, it is more concentrated than body fluids
  1. Because filtrate is hypotonic when it enters ascending limb, this allows the kidney to secrete urine that is more dilute than body fluids