Download Vet Pharmacology Test chapter 16 | VET 101 - Intro to Veterinary Techology and more Quizzes Veterinary medicine in PDF only on Docsity!
RBCs
formed in bone marrow in response to stimulation by erthropietin ( Chemical released by kidneys when hypoxia is present)Primary function-carry oxygen to tissues; greatly enhanced by hemoglobin TERM 2
Anemia-
DEFINITION 2 result form excessive loss of RBC, formation of inadequate numbers of RBC, or inadequate amounts of hemoglobin RBC. TERM 3
Iron compound
DEFINITION 3 clinical use: prevention or treatment of baby pig anemia or as nutritional aidadverse effects: rare-muscle weakness , prostration, or muscle discoloration.Dosage: Pet Tinic TERM 4
Erythropoietin-
DEFINITION 4 Protein produced in the kidneys that stimulates division & differentiation of committed erythroid precursors in bone marrow. Clinical Use: treatment of anemia associated with chronic renal failure or other causesAdverse effects: humans: hypertension, iron deficiency, polycythemia, & seizures TERM 5
Anticoagulants Heparin-
DEFINITION 5 found in many tissue of the body, thought to be stored in mast cellsclinical use: to preserve blood samples for testing, diluted insterile saline for flush solution for preventing clots in IV catheters, to preserve donated blood for transfusions, & treatment of DIC & thromboembolism.Adverse effects: bleeding of thrombocytopenia
Anticoagulants EDTA
(ethylenediaminetetraacetic Acid)
prevents clotting by chelation of calcium ( factor IV)Clinical use: preserve blood especially for differential count, treatment of lead poisoning. TERM 7
Anticoagulant Acid Citrate Dextrose Solution
(ACD)
DEFINITION 7 Clinical use: preserves blood (for 3-4 weeks)Dosage: prepared in bottles or bags for blood collection TERM 8
Anticoagulant Antiplatelet Drugs Asprin-
DEFINITION 8 Impair clotting through inhibition of platelet stickiness & clumpingIts used to prevent thromoboembolism associated with heartworm treatment in dogs & cardiomyopathy in cats TERM 9
Hemostatic/ Anticoagulants Antagonists
topical agents-
DEFINITION 9 provide framework in which clot may form or gelatins & collagensClinical Use: control capillary bleeding at surgical sites or in superficial woundsAdverse effects: minimal, may cause delayed wound healing TERM 10
Protamine Sulfate-
DEFINITION 10 Clinical use: treatment of Heparin overdoseAdverse effect: hypotension & bradycardia if given too rapidly
Tumor-
any tissue mass or swelling: may or may not be neoplastic TERM 17
Alkylating Agents Cell-cycle nonspecific
drugs
DEFINITION 17 able to cross link strands of DNA to change its structure & inhibit its replicationClinical Use: tx various neoplastic disorders: lymphoproliferative neoplasms, osteosarcoma, hemangiosarcoma, & squamous cell carcinoma. Tx certain immune-mediated diseases.Adverse Effects: neutropenia, nephrotoxicity, thrombocytopenia, vomiting, & hemorrhagic cystits. TERM 18
Anthracyclines
DEFINITION 18 clinical use: of lymphorproliferative neoplasms & various carcinomas & sarcomasAdverse effects: myelosuppression, cardiotoxicity, gastroenteritis, & anaphylaxis.Derived form soil fungi of streptomyces genus, cell cycle nonspecific & exert effects by binding with DNA- interfering with RNA & protein synthesis. TERM 19
Antimetabolics
DEFINITION 19 cell cycle specific: affects S-phaseClinical use: treatment of Lymphoproliferative neoplasms Gastrointestinal & hepatic neoplasms CNS lymphoma Adverse Effects: anorexia, nausea, vomiting, dirarrhea, bone marrow suppression, hepatotoxicity, & neurotoxicity TERM 20
Antitublin Agents
DEFINITION 20 Plant alkaloids-cell cycle specific for M-phase-inhibiting mitosis & causing cell deathClinical use: treatment of Lymphoproliferative neoplasms carcinomas mast cell tumors splenic tumor Adverse effects: Gastroenteritis, myelosuppression, stomatitis, alopecia, & peripheral neuropathy
Platinum
thought to interrupt replication of DNAClinical use: variety of solid tumors: osteosarcomas & carcinomasAdverse Effects: nephrotoxicity, nausea, anorexia, & vomiting ( more with Cisplatin); dyspnea, pulmonary edema, & death TERM 22
Asparaginase
DEFINITION 22 Cell cycle specific for G-1: acts as a catalyst in breakdown of asparagine (amino acid requires by cancer cells), without amino acid cancer cell dies.Clinical Use: tx of lymphoproliferative neoplasmsadverse effects: immediate hypersensitivity & GI disturbances TERM 23
Biologica Response Modifiers
DEFINITION 23 alter relationship between tumor & host animal in a way that improves host's ability to mount an antitumor response TERM 24
Interferon
DEFINITION 24 clinical use: amelioration of FeLV & FIP related conditionChemical produced by leukocytes, fibroblasts, & epithelial cells, can exert antitumor, antiviral, & immunoregulatory effects TERM 25
Acemannan-
DEFINITION 25 tx fibrosarcomas in dogs & cats
