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Signal Transduction: An Overview of G Protein-Coupled Receptors and Phosphoinositides, Quizzes of Cellular and Molecular Biology

Definitions and explanations of key terms related to signal transduction, specifically focusing on g protein-coupled receptors (gpcrs) and phosphoinositides. Gpcrs are a group of receptors that span the plasma membrane seven times, and their binding to ligands causes a conformational change that increases their affinity for a heterotrimeric g protein, initiating a response within the cell. Phosphoinositides, a negatively charged phospholipid, play a role in the cytosolic side of eukaryotic cell membranes. Irss (insulin receptor substrates) are protein substrates that get phosphorylated in response to insulin, binding and activating various 'downstream' effectors.

Typology: Quizzes

2009/2010

Uploaded on 11/08/2010

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TERM 1
signal transduction
DEFINITION 1
the overall process in which information carried by
extracellular messenger molecule is translated into changes
that occur inside the cell
TERM 2
GPCR
DEFINITION 2
G protein couled receptor
TERM 3
G protein-coupled receptor
DEFINITION 3
a group of related receptors that span the plasma membrane
seven times. the binding of this ligand to its specific receptor
causes a chang in the conformation of the receptor tha
increases it afinity for a heterotrimic G protein initiating a
response within the cell.
TERM 4
phosphoinositides
DEFINITION 4
Phosphatidylinositol (abbreviated PtdIns, or PI) is a
negatively charged phospholipid and a minor component in
the cytosolic side of eukaryotic cell membranes.
TERM 5
GTP-binding protein(G
protein)
DEFINITION 5
can be present in at least two alternate conformations, as
acitive GDP molecules
pf2

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TERM 1

signal transduction

DEFINITION 1 the overall process in which information carried by extracellular messenger molecule is translated into changes that occur inside the cell TERM 2

GPCR

DEFINITION 2 G protein couled receptor TERM 3

G protein-coupled receptor

DEFINITION 3 a group of related receptors that span the plasma membrane seven times. the binding of this ligand to its specific receptor causes a chang in the conformation of the receptor tha increases it afinity for a heterotrimic G protein initiating a response within the cell. TERM 4

phosphoinositides

DEFINITION 4 Phosphatidylinositol (abbreviated PtdIns, or PI) is a negatively charged phospholipid and a minor component in the cytosolic side of eukaryotic cell membranes. TERM 5

GTP-binding protein(G

protein)

DEFINITION 5 can be present in at least two alternate conformations, as acitive GDP molecules

TERM 6

IRSs (meaning)

DEFINITION 6 Insulin receptor substrate TERM 7

IRSs

DEFINITION 7 protein substrate that when phosphorylated in response to insulin, bind and activates a variety of 'downstream' effectors