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Young Miki from 90s Survive with Areata Alopecia: A Case Study.

PART ONE: Review of the Genetic Case

The patient throughout this case study does have Alopecia called Areata. The National

Health Institute describes Alopecia areata as a condition that results in hair loss when the

immune system destroys hair follicles. Where these parts of the skin that produce hair are called

hair follicles. While alopecia areata can affect any body region, the head and face are most

frequently affected.

Causes and Manifestations of the Genetic Case

According to doctors and experts, alopecia areata doesn't have one definitive cause.

Researchers have offered that Genetics, Unbalanced Hormones, Adrenal Fatigue,

Diet/Food/Lifestyle/Environment, and Stress can cause Alopecia Areata.

●Genetics: Both parents' genes contribute to Alopecia, a polygenic disorder. Patients are

more vulnerable if there is a genetic predisposition to these other autoimmune diseases.

●Unbalanced hormones: High amounts of either testosterone or estrogen can lead to

baldness in both men and women. Yet, while some women's Alopecia may be brought on

by an oversensitivity to the androgens within birth control pills, it's noteworthy that some

women say that Alopecia gets better during pregnancy.

●Adrenal fatigue: An inflammatory reaction causes Alopecia, an autoimmune disease.

This adrenal dysfunction may impact the body's natural capacity to manage short-term

and long-term stress.

●Food, lifestyle, and environment: Alopecia can be brought on by external causes and

gut health in those susceptible to the illness.

●Stress is frequently regarded as the primary culprit producing Alopecia, whether internal

such as diet-related inflammation, or external such as a tragedy or losing one's work.

Disease Mechanisms and Pathway

Proinflammatory signals, such as substance P and interferon-c, upregulate the expression

of the complex of major histocompatibility class Ia within the hair follicle, causing alopecia

areata in genetically susceptible people. Interferon (IFN) has been shown to be the most effective

in vivo inducer of ectopic Major histocompatibility complex (MHC I expression within murine

anagen hair bulbs. In genetically sensitive C3H/HeJ mice, systemic administration of IFN-c

stimulated the growth of AA in conjunction with MHC class I and class II expression throughout

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Young Miki from 90s Survive with Areata Alopecia: A Case Study.

PART ONE: Review of the Genetic Case The patient throughout this case study does have Alopecia called Areata. The National Health Institute describes Alopecia areata as a condition that results in hair loss when the immune system destroys hair follicles. Where these parts of the skin that produce hair are called hair follicles. While alopecia areata can affect any body region, the head and face are most frequently affected. Causes and Manifestations of the Genetic Case According to doctors and experts, alopecia areata doesn't have one definitive cause. Researchers have offered that Genetics, Unbalanced Hormones, Adrenal Fatigue, Diet/Food/Lifestyle/Environment, and Stress can cause Alopecia Areata. ● Genetics: Both parents' genes contribute to Alopecia, a polygenic disorder. Patients are more vulnerable if there is a genetic predisposition to these other autoimmune diseases. ● Unbalanced hormones: High amounts of either testosterone or estrogen can lead to baldness in both men and women. Yet, while some women's Alopecia may be brought on by an oversensitivity to the androgens within birth control pills, it's noteworthy that some women say that Alopecia gets better during pregnancy. ● Adrenal fatigue: An inflammatory reaction causes Alopecia, an autoimmune disease. This adrenal dysfunction may impact the body's natural capacity to manage short-term and long-term stress. ● Food, lifestyle, and environment : Alopecia can be brought on by external causes and gut health in those susceptible to the illness. ● Stress is frequently regarded as the primary culprit producing Alopecia, whether internal such as diet-related inflammation, or external such as a tragedy or losing one's work. Disease Mechanisms and Pathway Proinflammatory signals, such as substance P and interferon-c, upregulate the expression of the complex of major histocompatibility class Ia within the hair follicle, causing alopecia areata in genetically susceptible people. Interferon (IFN) has been shown to be the most effective in vivo inducer of ectopic Major histocompatibility complex (MHC I expression within murine anagen hair bulbs. In genetically sensitive C3H/HeJ mice, systemic administration of IFN-c stimulated the growth of AA in conjunction with MHC class I and class II expression throughout

the follicular epithelium. As activated T cells are the main generator of IFN-c, an immune system activation might occur before an immune privilege is lost (McElwee et al., n.d.). An autoimmune disease called Alopecia causes healthy hair follicles to be mistakenly attacked by the immune system. As a result, the follicles contract, slowing down and eventually stopping hair growth. This disruption in the hair-growing cycle results in an early transition from the anagen (growth) phase to that same telogen (resting) phase, blocking hair formation above the surface lasting months or even years. Alopecia can cause circular shape oval bald patches of varying proportions in both men and women. Occasionally the hair may grow back on its own without any medical intervention. In other situations, the patches would spread, and the patient would go through a prolonged rest period. These hair follicles are still functional throughout alopecia areata. This new hair can grow somehow at any time. Incidence Rate Locally 50% of Filipino men will have hair loss by the time they are 40, in accordance with the Philippine Council for Health Research and Development (PCHRD). Due to such hormone testosterone being transformed into a secondary chemical called DHT, this is the most prevalent kind of gradual hair loss in both men and women worldwide. In addition, the poll revealed that 20% of males felt less physically appealing to others whenever patchy baldness started to appear, and 15% of participants said that losing their hair directly caused them to lose confidence and self-esteem. Expert on hair loss Dr. Jun Bormante stated that although society regards and treats men with androgenic alopecia as a significant influence in how they view themselves, the illness is curable. Patients should seek medical care as soon as possible. Globally Worldwide, alopecia areata occurs. A lifetime risk of about 2% is associated with an estimated prevalence of about 1 in 1000 persons. Alopecia areata can affect anybody, including children and adults, and both sexes experience it at about the same rates. The average age at which alopecia areata was diagnosed in males and females in Olmsted County, Minnesota, between the years 1990 and the year 2009 was 32 years and 36 years, respectively. The incidence of AA throughout the course of a lifetime is about 2% globally. In none of the official population, studies was there a sex bias. Although it can happen at any age, the second and subsequent decades of life are when the first onset would be most frequent. A greater lifetime risk of severe illness is correlated with a younger age of

so obvious. While a skin biopsy is not always necessary, her parents chose to submit to the procedure. Young Miki was determined to have Areata-classified alopecia. Miki's parents had no idea their sole child would be afflicted with this condition. In addition to sending Miki to a specialist doctor for treatment, her parents were always in prayer. While there was no known cure for alopecia throughout the years she suffered, some potential treatments could still be available. The doctor advised Young Miki to cover her head with a scarf so she would be less exposed to the sun's rays. Young Miki has been bullied because of her illness, but her parents refuse to stop caring for her. Despite this, Miki's parents continue to seek more medical care for her by purchasing any ointment or natural remedy to help her hair grow. Family History Her mother's great-grandmother experienced this type of hair loss as a teenager. Thus, it runs in the family. This led to the conclusion that Young Miki's alopecia was an inherited condition from her mother. ANOTHER PICTURE OF YOUNG MIKI After receiving prayers and medical care, Young Miki overcame her alopecia areata. Where her hair had regrown, it was healthy. Her Alopecia Areata symptoms did not show till she was in her 20s. Her hair returned to normal and got fitter. PART THREE: Conclusions An ongoing inflammatory condition is alopecia areata, which occasionally affects the nails and hair follicles. There is no known race or gender predominance, and the onset can occur at any age. Alopecia areata often manifests as patches with hair loss upon the scalp. However, it can affect any skin that has hair. Though it could be slightly reddish, the afflicted skin overall seems normal. The edges of alopecia areata growing patches typically have short, broken strands (exclamation mark hairs). The possible genetic illness known as alopecia areata, which weakens immune systems, causes hair loss and leaves a circular patch on the scalp, was experienced by a little girl named Miki. Due to her parents' desire for her to get well and have a normal life like the other children, little Miki didn't skip any of her treatments. Her hair returned to normal and started to look healthier as a consequence, which continued until this year. Alopecia areata (AA), an autoimmune condition that affects the hair follicle, can strike at any age and leaves no visible scars. A dermatology clinic frequently sees pediatric cases, and managing them can be difficult in certain situations. A tiny percentage of these patients have a

chronic relapsing trajectory characterized by unpleasant hair loss, which can result in severe mental morbidity. We discuss effective second and third-line medications in addition to the accepted medicines for juvenile alopecia areata. As a manual for treating pediatric AA, we must also provide a therapy algorithm. For instance, the pediatric dermatologists at Nationwide Children's would suggest topical steroids, steroid injections, topical minoxidil (Rogaine), topical irritants, immunotherapy, or immune-suppressing medications.

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Young Miki from 90s Survive with Areata Alopecia: A Case Study.